Endocarditis Diagnostic Criteria — Duke Criteria

Select Criteria:

Major Diagnostic Criteria

Positive blood culture for typical Infective Endocarditis organisms (strep viridins or bovis, HACEK, staph aureous without other primary site, enterococcus), from 2 separate blood cultures or 2 positive cultures from samples drawn > 12 hours apart, or 3 or a majority of 4 separate cultures of blood (first and last sample drawn 1 hour apart)

Echocardiogram with oscillating intracardiac mass on valve or supporting structures, in the path of regurgitant jets, or on implanted material in the absence of an alternative anatomic explanation, or abscess, or new partial dehiscence of prosthetic valve or new valvular regurgitation

Minor Diagnostic Criteria

Predisposing heart condition or intravenous drug use

Temp > 38.0° C (100.4° F)

Vascular phenomena: arterial emboli, pulmonary infarcts, mycotic aneurysms, intracranial bleed, conjunctival hemorrhages, Janeway lesions

Immunologic phenomena: glomerulonephritis, Osler nodes, Roth spots, rheumatoid factor

Microbiological evidence: positive blood culture but does not meet a major criterion as noted above or serological evidence of active infection with organism consistent with endocarditis (excluding coag neg staph, and other common contaminants)

Echocardiographic findings: consistent with endocarditis but do not meet a major criterion as noted above

Minor Criteria

Major Criteria

Diagnostic : 2 Major Criteria and 0 Minor Criteria

Diagnostic : 1 Major Criteria and 3 Minor Criteria

Diagnostic : 0 Major Criteria and 5 Minor Criteria

* Required

References

Clin Infect Dis. 2000 Apr;30(4):633-8.Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Li JS1, Sexton DJ, Mick N, Nettles R, Fowler VG Jr, Ryan T, Bashore T, Corey GR.
Durack DT, Lukes AS, Bright DK. New criteria for diagnosis of infective endocarditis: utilization of specific echocardiographic findings. Duke Endocarditis Service. American Journal of Medicine. 96(3):200-9, 1994.
Lukes AS, Bright DK, Durack DT. Diagnosis of infective endocarditis. Infect Dis Clin North Am. 1993 Mar;7(1):1-8. Review.

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